I know this is a bizzare and almost blasphemous picture. Bear with me while I explain.
I believe those with the eye-popping signs are followers of Fred Phelps, an extremist christian. These groups look up events where large amounts of people will be present, then set up these signs and claim that the apocalypse will come, that everyone must repent, that we are all sinners and must embrace Jesus and God.
With the exception that they single out many minorities, including gays, lesbians, jewish followers, islams, mormons, and those of us who are "lazy" and "waste our time with foolishness of entertainment". They targeted the anime convention because we supposedly waste our time in pointless crap when we should be spending our time repenting and condemming those that are "not worthy of the Lord's forgiveness".
I know this because of a play I did in high school, "The Laramie Project", and because these very protesters came to my school last semester.
At some point, a random cosplayer dressed as Jesus hopped up onto the pedestal behind the protesters. He was by no means supporting these people.
Attendants of the convention called out to him, asking if he accepts and forgives. "Jesus" replied with "I love all, forgive all, and accept all. I love you all!"
I'm sure a few people were offended, but the words of the protesters hurt a lot. Having heard them myself, it saddens me that someone thinks condemming with such interpretations and words actually THINK they themselves will fall into the Lord's grace.
And it offends me when they condemn others with different beliefs.
The protesters left about an hour or two after this. It was by far an interesting highlight of the convention.
Taken at FanimeCon 2008